Citrus Juice

Common Name: Citrus Juice

Clinical Names:

Summary

Citrus Juice

overview of interactions:
• nutrient affecting drug toxicity: Aluminum Hydroxide (Antacids)

Interactions

nutrient affecting drug toxicity: Aluminum Hydroxide (Antacids)

• mechanism: Consumption of citrus juice substantially enhances aluminum absorption from antacids.

• research: Research done at the Institute of Food Research found that urinary aluminum increased by a factor of 10 in 24 hours when Aludrox, an aluminum antacid, and orange juice were ingested together.
(Fairweather-Tait S, et al. Eur J Clin Nutr 1994 Jan;48(1):71-73.)

• nutritional concerns: Citric acid containing substances should not be taken with aluminum antacids.

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Do not rely solely on the information in this article.

The information presented in Interactions is for informational and educational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, case reports, and/or traditional usage with sources as cited in each topic. The results reported may not necessarily occur in all individuals and different individuals with the same medical conditions with the same symptoms will often require differing treatments. For many of the conditions discussed, treatment with conventional medical therapies, including prescription drugs or over-the-counter medications, is also available. Consult your physician, an appropriately trained healthcare practitioner, and/or pharmacist for any health concern or medical problem before using any herbal products or nutritional supplements or before making any changes in prescribed medications and/or before attempting to independently treat a medical condition using supplements, herbs, remedies, or other forms of self-care.


References

Fairweather-Tait S, Hickson K, McGaw B, Reid M. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr 1994 Jan;48(1):71-73.
Abstract: Aluminium absorption from four doses of the antacid preparation 'Aludrox' when taken alone, with orange juice or with milk was compared by measuring the change in urinary aluminium following Aludrox dosage in 15 normal adults. There was an approximately 10-fold increase in 24 h urinary aluminium excretion following the Aludrox plus orange juice (232 micrograms) which was significantly higher than that following Aludrox alone (62 micrograms) (P < 0.001), but milk had no effect on aluminium absorption. The results showed that orange juice greatly enhanced aluminium absorption and should not therefore be taken in conjunction with aluminium-containing antacid preparations.